CONCOMITANT ANAPHYLACTIC SENSITIZATION AND CONTACT UNRESPONSIVENESS FOLLOWING THE INFUSION OR FEEDING OF PICRYL CHLORIDE TO GUINEA PIGS
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چکیده
منابع مشابه
Concomitant Anaphylactic Sensitization and Contact Unresponsiveness following the Infusion or Feeding of Picryl Chloride to Guinea Pigs
Guinea pigs receiving one large dose of picryl chloride by the intravenous or oral routes commonly develop circulating antibody demonstrable by passive cutaneous anaphylaxis or by active anaphylaxis. They often concommittantly become unresponsive to the induction of delayed contact hypersensitivity by intracutaneous injections. Erythrocytes obtained from guinea pigs after infusion or feeding of...
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Normal guinea pigs fed chemical haptens develop a specific state of unresponsiveness, inhibiting subsequent development of dermal sensitization with the same hapten and modifying profoundly the synthesis of anaphylactic antibody in response to hapten conjugated to guinea pig proteins. The degree of unresponsiveness has been tested by exposing hapten-fed animals to intense haptenic stimulation. ...
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1. Attempts to produce anaphylactic shock in white rats by second intravenous or subdural injections of horse serum have failed. 2. It was impossible to demonstrate either by skin reactions or by the uterine reaction that white rats can be sensitized to horse serum. 3. It was not possible to sensitize guinea pigs passively with the serum of white rats presumably immunized to horse serum. 4. In ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1966
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.124.1.69